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Precision Medicine


What Is Precision Medicine?

Precision medicine — also called "personalized medicine" or "genomic medicine" — is a way to guide the prevention, diagnosis, and treatment of diseases based on the person's individual genes, environment, and lifestyle.

Is Precision Medicine New?

Many people first heard about precision medicine in 2015 when President Barack Obama launched the Precision Medicine Initiative. This ambitious plan's goal is to gather genetic information from 1 million or more Americans to aid in the development of personalized, genetics-based medical treatments.

What Do Genes Have to Do With Precision Medicine?

The launch of precision medicine came when the international Human Genome Project successfully sequenced the human genome — "decoding" human DNA and identifying the genes that it contains. Most of our cells contain a complete set of DNA, the operating instructions that influence everything from a person's hair color to susceptibility to disease.

How Does Precision Medicine Work?

Precision medicine helps health care providers better understand the many things — including environment, lifestyle, and heredity — that play a role in a patient's health, disease, or condition. This information lets them more accurately predict which treatments will be most effective and safe, or possibly how to prevent the illness from starting in the first place.

Let's use cancer as an example:

Patient Smith is diagnosed with cancer. Doctors use diagnostic tests (biopsies, lab tests, etc.) to "grade" the cancer; for example, to see how large a tumor is or whether the cancer has spread.

Now, for patients with some kinds of cancers (such as breast, lung, colorectal, melanoma, and leukemias), molecular genetic testing can be a tool to guide more individualized and effective care. The testing finds differences (called mutations) in the genes in the person's cancer cells. This helps doctors decide which treatments might improve survival and minimize side effects.

Drug treatment decisions for some diseases, like cystic fibrosis, is another example of precision medicine in action:

Cystic fibrosis is a genetic chronic disease that leads to severe lung problems and damage to other organs and body tissues. Molecular genetic testing has shown that many different gene mutations can cause it. A new (and very expensive) drug developed to treat cystic fibrosis is only effective in people who have certain specific gene mutations causing their disease. So genetic testing of patients with cystic fibrosis can help doctors identify which patients benefit from treatment with the drug.

Are There Problems or Limitations With Precision Medicine?

Although use of a person's genetic profile to guide health care decisions will certainly become more common and helpful as time goes on, there are a number of issues to consider:

Should My Child Have Molecular Genetic Testing?

It depends on your child's condition, and whether there is a genetic test available that's helpful for making a decision about your child's diagnosis or treatment. If you have questions about this, ask your child's doctor. Genetic testing is most appropriately performed with the help of genetic counselors or geneticists, who are trained in the evaluation of molecular tests and their results and implications.

Date reviewed: October 2017


Note: All information on KidsHealth® is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor.

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